PRIMARY STUDY

Regional Changes in the Type 1 Cannabinoid Receptor Are Associated With Cognitive Dysfunction in Parkinson's Disease

Key Findings:  PET scan of participating Parkinson's patients showed decreased CB1 receptor sites in portions of the brain strongly correlated with ill-effects in executive functioning, episodic memory, and visuospatial functioning.

Type of Study:  Meta-analysis

Study Sample Size:  38

Study Result:  Inconclusive

Research Location(s):  Belgium

Year of Pub:  2019


Cannabinoids Studied: 

Phytocannabinoid Source:  Not Applicable

Receptors Studied:  CB1




Citation:  Ceccarini J, et al. Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson's disease. Eur J Nucl Med Mol Imaging. 2019; 46:2348-2357. doi: 10.1007/s00259-019-04445-x

Authors:  Ceccarini J, Casteels C, Ahmad R, Crabbé M, Van de Vliet L, Vanhaute H, Vandenbulcke M, Vandenberghe W, Van Laere K