Key Findings:  Pharmacological modulation of the eCB system ( Figure 3) has been shown to reduce chronic activation of the neuroinflammatory response, aid in Ca2+ homeostasis, reduce oxidative stress, mitochondrial dysfunction and the resulting proapoptotic cascade, while promoting neurotrophic support.
Type of Study:  Meta-analysis
Study Result:  Positive
Research Location(s):  Ireland
Year of Pub:  2014
Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), SR-x Synthetic Cannabinoids, Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG)
Phytocannabinoid Source:  Not Applicable
Receptors Studied:  CB1, CB2
Ligands Studied:  Glutamate
Citation:  Fagan SG and Campbell VA. The influence of cannabinoids on generic traits of neurodegeneration. Br J Pharmacol. 2014; 171:1347-60. doi: 10.1111/bph.12492
Authors:  Fagan SG, Campbell VA