Amyloid Proteotoxicity Initiates An Inflammatory Response Blocked By Cannabinoids

Key Findings:  Cannabinoids such as tetrahydrocannabinol stimulate the removal of intraneuronal beta amyloid (Aβ), block the inflammatory response, and are protective. Altogether these data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accumulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors.

Type of Study:  Laboratory Study

Study Result:  Positive

Cannabinoids Studied:  Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, Anandamide (AEA)

Phytocannabinoid Source:  Not Applicable

Form of Administration:  Not Applicable

Receptors Studied:  CB1, CB2

Study Location(s):  United States

Year of Pub:  2016

Link to study