PRIMARY STUDY
The protective effects of β-caryophyllene on LPS-induced primary microglia M1/M2 imbalance: A mechanistic evaluation.
Key Findings: In conclusion, the low concentration of BCP has higher selective anti-inflammatory effects rather than high levels. On this occasion, BCP by modulating the microglia is able to have potential therapeutic effects in neuro-inflammation conditions and microglia cells such as MS and AD.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Iran
Year of Pub: 2018
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2, PPAR - Gamma
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Route of Administration: In vitro
Citation: Askari VR and Shafiee-Nick R. The protective effects of β-caryophyllene on LPS-induced primary microglia M1/M2 imbalance: A mechanistic evaluation. Life Sci. 2019; 219:40-73. doi: 10.1016/j.lfs.2018.12.059
Authors: Askari VR, Shafiee-Nick R
