PRIMARY STUDY
Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death.
Key Findings: Treatment of mice with cannabidiol markedly attenuated the cisplatin-induced oxidative/nitrosative stress, inflammation, and cell death in the kidney, and it improved renal function. Thus, the results suggest that cannabidiol may represent a promising new protective strategy against cisplatin-induced nephrotoxicity.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China, United States
Year of Pub: 2009
Cannabinoids Studied: Cannabidiol (CBD)
Chemotype: Chemotype III
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Sub-Ratio: 0:1 (THC:CB
Dosage: CBD (2.5 to 10 mg/kg i.p. daily, starting 1.5 h before the cisplatin exposure)
Route of Administration: Injection
Citation: Pan H, et al. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther. 2009; 328:708-14. doi: 10.1124/jpet.108.147181
Authors: Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Haskó G, Pacher P
