PRIMARY STUDY

CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate‐Induced Excitotoxicity Through a Reduction of NOX‐2 Activity and Oxidative Stress

Key Findings:  The activation of CB1-induced neuroprotective effects during excitotoxicity. WIN55,212‐2 reduced brain edema, ROS, neuroinflammation, and aquaporin 4 (AQP4), a water channel implicated in blood-brain-barrier (BBB) permeability and edema formation.