PRIMARY STUDY
Cafeteria Diet Abstinence Induces Depressive Behavior and Disrupts Endocannabinoid Signaling in Dopaminergic Areas: A Preclinical Study
Key Findings: In mice abstinence from a cafeteria diet was linked to neuroadaptive changes in monoamines and endocannabinoid signaling in brain areas partaking to dopamine transmission. These changes could partially be restored by the enhancement of endocannabinoid signaling through fatty acid amide hydrolase (FAAH) inhibition.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy, Spain
Year of Pub: 2024
Cannabinoids Studied: Fatty Acid Amide Hydrolase (FAAH), Diet
Phytocannabinoid Source: Not Applicable
Ligands Studied: Dopamine
Citation: de Ceglia M, et al. Cafeteria Diet Abstinence Induces Depressive Behavior and Disrupts Endocannabinoid Signaling in Dopaminergic Areas: A Preclinical Study. Curr Neuropharmacol. 2024; (unknown volume):(unknown pages). doi: 10.2174/1570159X23666241107160840
Authors: de Ceglia M, Romano A, Micioni Di Bonaventura MV, Gavito A, Botticelli L, Micioni Di Bonaventura E, Friuli M, Cifani C, Rodríguez de Fonseca F, Gaetani S
