PRIMARY STUDY

Serum Metabolomics Analysis Revealed Metabolic Pathways Related to AECOPD Complicated with Anxiety and Depression

Key Findings:  This retrospective identified the key metabolites and metabolic pathways that are altered in patients with anxiety, depression, and acute exacerbation of chronic obstructive pulmonary disease (AECOPD). There were 134 metabolites in 18 pathways, that involved unsaturated fatty acids, aldosterone synthesis and secretion, protein digestion and absorption, ovarian steroidogenesis, long-term depression, retrograde endocannabinoid signaling among others.