PRIMARY STUDY
Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume
Key Findings: Major depressive disorder (MDD) was associated with higher serum anandamide (AEA) levels compared to healthy participants. MDD was also associated with higher and 2-arachidonylglycerol (2-AG) and childhood maltreatment (CM).
Type of Study: Meta-analysis
Study Sample Size: 153
Study Result: Negative
Research Location(s): Canada, Sweden, United States
Year of Pub: 2024
Cannabinoids Studied: Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Citation: Mazurka R, et al. Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume. Transl Psychiatry. 2024; 14:431. doi: 10.1038/s41398-024-03151-z
Authors: Mazurka R, Harkness KL, Hassel S, Stensson N, Nogovitsyn N, Poppenk J, Foster JA, Squires SD, Rowe J, Milev RV, Wynne-Edwards KE, Turecki G, Strother SC, Arnott SR, Lam RW, Rotzinger S, Kennedy SH, Frey BN, Mayo LM
