PRIMARY STUDY
Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy.
Key Findings: In experimental type 1 diabetes, the CB1 receptor is overexpressed by glomerular podocytes, and blockade of the CB1 receptor (via AM-251) ameliorates albuminuria possibly via prevention of nephrin, podocin, and ZO-1 loss.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2012
Cannabinoids Studied: AM-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Citation: Barutta F, et al. Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy. Diabetes. 2010; 59:1046-54. doi: 10.2337/db09-1336
Authors: Barutta F, Corbelli A, Mastrocola R, Gambino R, Di Marzo V, Pinach S, Rastaldi MP, Perin PC, Gruden G
