PRIMARY STUDY

Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials

Key Findings:  This study assessed the impact of metformin or dietary-induced weight loss on biomarkers of kidney dysfunction in patients with autosomal dominant polycystic kidney disease (ADPKD). Results found that the values of kidney injury molecule-1, fatty-acid binding protein, interleukin-18, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalin, clusterin, and human cartilage glycoprotein-40 did not change, nor did they associate values with kidney disease progression.