PRIMARY STUDY
Kidney Damage and Stress Biomarkers for Early Identification of Drug-Induced Kidney Injury: A Systematic Review
Key Findings: This literature search finds several biomarkers that are potentially useful predictors of drug-induced AKI (DIAKI): β2-microglobulin (B2M), interleukin (IL)-18, kidney injury molecule-1 (KIM-1), liver-type fatty acid-binding protein (L-FABP), neutrophil gelatinase-associated lipocalin (NGAL), and tissue inhibitor of metalloproteinase-2 * insulin-like growth factor-binding protein 7 [TIMP-1]*[IGFBP-7].
Type of Study: Meta-analysis
Study Sample Size: 15
Study Result: Positive
Research Location(s): United States
Year of Pub: 2022
Cannabinoids Studied: Fatty Acid-Binding Protein (FABP)
Phytocannabinoid Source: Not Applicable
Ligands Studied: Insulin
Route of Administration: Endogenous
Citation: Desai RJ, et al. Kidney Damage and Stress Biomarkers for Early Identification of Drug-Induced Kidney Injury: A Systematic Review. Drug Saf. 2022; 45:839-852. doi: 10.1007/s40264-022-01202-2
Authors: Desai RJ, Kazarov CL, Wong A, Kane-Gill SL
