PRIMARY STUDY
Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress and cell death in nephropathy.
Key Findings: Research shows that treatment of mice with a CB2 receptor agonist HU-308 attenuates cisplatin-induced increased chemokine production and inflammatory cell infiltration in the kidney, and the consequent release of reactive oxidants and inflammatory mediators, leading to decreased cell death in tubular cells associated with marked improvement of the cisplatin-induced compromised renal function.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China, United States
Year of Pub: 2010
Cannabinoids Studied: HU-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Route of Administration: Injection
Citation: Mukhopadhyay P, et al. Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy. Free Radic Biol Med. 2010; 48:457-67. doi: 10.1016/j.freeradbiomed.2009.11.022
Authors: Mukhopadhyay P, Rajesh M, Pan H, Patel V, Mukhopadhyay B, Bátkai S, Gao B, Haskó G, Pacher P
