PRIMARY STUDY
Effect of Cannabidiol Oil on Post-ureteroscopy Pain for Urinary Calculi: A Randomized, Double-blind, Placebo-controlled Trial
Key Findings: This study looked at adding cannabidiol (CBD) oil, versus placebo, to standard opioid pain regimens to reduce post-ureteroscopic stent pain. Results found no difference in pain scores or the amount of opioid usage between the two groups. CBD was deemed safe and well tolerated, but its pain-relieving properties were ineffective.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 90
Study Result: Inconclusive
Research Location(s): Canada, United States
Year of Pub: 2023
Cannabinoids Studied: Cannabidiol (CBD), Pharma CBD
Phytocannabinoid Source: Cannabis Flower derived
Chemotype: Chemotype III
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: No effective dose
Route of Administration: Oral (Ingestion)
Cannabinoid Ratio: (Pharma CBD) 0 
Dosage Form: cannabidiol oil
Dosing Regimen: CBD (Epidiolex) 20 mg daily
Treatment Duration: for 3 days postoperatively
Clinical Relevance: There was no difference in pain scores or opioid usage between CBD or opioids postoperatively.
Citation: Narang G, et al. Effect of Cannabidiol Oil on Post-ureteroscopy Pain for Urinary Calculi: A Randomized, Double-blind, Placebo-controlled Trial. J Urol. 2023; 209:726-733. doi: 10.1097/JU.0000000000003139
Authors: Narang G, Moore J, Wymer K, Chang YH, Lim E, Adeleye O, Humphreys MR, Stern KL
