PRIMARY STUDY
CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder
Key Findings: This study outlines the CB1 and CB2 receptor mechanism in guinea pig bladder mucosal cells, and concludes that the anti-pain and anti-inflammatory properties of CB1 and CB2 receptor inhibition could be a viable target for the treatment of bladder related disorders like cystitis.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Australia
Year of Pub: 2021
Cannabinoids Studied: Anandamide (AEA), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, TRPV1, GPCR
Citation: Christie S and Zagorodnyuk V. CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder. Am J Physiol Renal Physiol. 2021; 320:F859-F865. doi: 10.1152/ajprenal.00065.2021
Authors: Christie S, Zagorodnyuk V
