PRIMARY STUDY
Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function
Key Findings: This study explores the complex mechanisms by which the CB1 receptors control glucose control and thus kidney function in mice, and suggests potential therapeutic targets within the endocannabinoid system for the treatment of diabetic kidney disease.
Type of Study: Animal Study
Study Result: Inconclusive
Research Location(s): Hungary, Israel, Switzerland
Year of Pub: 2022
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1
Ligands Studied: Insulin
Route of Administration: Injection
Citation: Hinden L, et al. Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function. Nat Commun. 2022; 13:1783. doi: 10.1038/s41467-022-29124-8
Authors: Hinden L, Ahmad M, Hamad S, Nemirovski A, Szanda G, Glasmacher S, Kogot-Levin A, Abramovitch R, Thorens B, Gertsch J, Leibowitz G, Tam J
