PRIMARY STUDY
The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).
Key Findings: The CAMS study randomised 630 patients to receive oral administration of cannabis extract, Delta(9)-tetrahydrocannabinol (THC) or matched placebo. All three groups showed a significant reduction symptoms: cannabis extract, 38%; THC, 33%; and placebo, 18%. Both active treatments showed significant effects over placebo. The findings are suggestive of a clinical effect of cannabis on incontinence episodes in patients with MS.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 630
Study Result: Positive
Research Location(s): United Kingdom
Year of Pub: 2006
Cannabinoids Studied: Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Not Applicable
Chemotype: Chemotype I
Sub-Ratio: 1:0 (THC:CBD)
Route of Administration: Oral (Ingestion)
Citation: Freeman RM, et al. The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS). Int Urogynecol J Pelvic Floor Dysfunct. 2006; 17:636-41. doi: 10.1007/s00192-006-0086-x
Authors: Freeman RM, Adekanmi O, Waterfield MR, Waterfield AE, Wright D, Zajicek J
