PRIMARY STUDY
A Preliminary Controlled Study To Determine Whether Whole-plant Cannabis Extracts Can Improve Intractable Neurogenic Symptoms
Key Findings: Pain relief associated with both THC and CBD was significantly superior to placebo. Impaired bladder control, muscle spasms and spasticity were improved by cannabis extract in some patients with these symptoms.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 24
Study Result: Positive
Research Location(s): United Kingdom
Year of Pub: 2003
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Cannabis Flower derived
Chemotype: Chemotype I, Chemotype II, Chemotype III
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Sublingual/Oromucosal
Cannabinoid Ratio: (THC : CBD) 1 : 1 
Dosage Form: sublingual spray
Dosing Regimen: THC, CBD, or 1:1 THC:CBD (At a range of 2.5–120 mg/24 hour)
Starting Dose: 2.5 mg/24 hours
Maximum Dose: 120 mg per 24 hours
Treatment Duration: 2 weeks
Citation: Wade DT, et al. A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clin Rehabil. 2003; 17:21-9. doi: 10.1191/0269215503cr581oa
Authors: Wade DT, Robson P, House H, Makela P, Aram J
