PRIMARY STUDY
Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization
Key Findings: Treatments with CBC + THC or CBD led to cell cycle arrest and cell apoptosis. Synergistic effects were observed between CBC + THC. In direct contrast, inverse agonism of CB1 and CB2 produced cytotoxic activity.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Israel
Year of Pub: 2021
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Cannabis Flower derived
Receptors Studied: CB1, CB2, TRPA1, TRPV1, TRPV2
Route of Administration: Injection
Citation: Anis O, et al. Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization. Molecules. 2021; 26:(unknown pages). doi: 10.3390/molecules26020465
Authors: Anis O, Vinayaka AC, Shalev N, Namdar D, Nadarajan S, Anil SM, Cohen O, Belausov E, Ramon J, Mayzlish Gati E, Koltai H
