PRIMARY STUDY
Bladder Cancer Cell Growth and Motility Implicate Cannabinoid 2 Receptor-Mediated Modifications of Sphingolipids Metabolism
Key Findings: Human bladder cancer cell lines (RT4, RT112) were treated with CB agonists to assess proliferation, apoptosis, and motility. The CB2 agonist JWH-015 induced anti-proliferative activity and inhibited bladder cancer cell growth.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Italy, Sweden, United States
Year of Pub: 2017
Cannabinoids Studied: JWH-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB2
Route of Administration: In vitro
Citation: Bettiga A, et al. Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism. Sci Rep. 2017; 7:42157. doi: 10.1038/srep42157
Authors: Bettiga A, Aureli M, Colciago G, Murdica V, Moschini M, Lucianò R, Canals D, Hannun Y, Hedlund P, Lavorgna G, Colombo R, Bassi R, Samarani M, Montorsi F, Salonia A, Benigni F
