PRIMARY STUDY
Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis
Key Findings: The authors hypothesize that by inhibiting the enzymes responsible for the catabolism of endogenous cannabinoids locally, bladder concentrations of CBR2 agonists will increase, particularly 2-arachidonyl glycerol, resulting in a diminished inflammatory response.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Canada
Year of Pub: 2019
Cannabinoids Studied: 2-Arachidonoyl Glycerol (2-AG)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB2
Citation: Chinnadurai A, et al. Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis. Med Hypotheses. 2019; 131:109321. doi: 10.1016/j.mehy.2019.109321
Authors: Chinnadurai A, Berger G, Burkovskiy I, Zhou J, Cox A, Lynch M, Lehmann C
