PRIMARY STUDY

CBGA ameliorates inflammation and fibrosis in nephropathy

Key Findings:  This study demonstrates that cannabigerolic acid confers superior renoprotective effects compared to cannabidiol in models of acute and chronic kidney injury by suppressing inflammation, apoptosis, and fibrosis—potentially via TRPM7 inhibition—while both cannabinoids reduce renal fibrosis and caspase-3 activity.

Type of Study:  Animal Study

Study Result:  Positive

Research Location(s):  United States

Year of Pub:  2026


Cannabinoids Studied:  Cannabidiol (CBD), Cannabigerol (CBG)

Phytocannabinoid Source:  Not Applicable

Ligands Studied:  Pro-inflammatory cytokines

Route of Administration:  , Injection




Citation:  Suzuki S, Fleig A, Penner R. CBGA ameliorates inflammation and fibrosis in nephropathy. Sci Rep. 2023 Apr 18;13(1):6341. doi: 10.1038/s41598-023-33507-2. PMID: 37072467; PMCID: PMC10113213.