PRIMARY STUDY
The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract
Key Findings: This review finds some preclinical data supporting a beneficial role of the endocannabinoid system (ECS), receptors, ligands, and regulatory proteins, in the lower urinary tract (LUT), but data are lacking on a significant role that modulation may play in the treatment of disorders or dysfunction of the LUT.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Germany, Sweden
Year of Pub: 2025
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, JWH-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Endocannabinoid (unspecified), Pharma THC:CBD, Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Not Applicable
Chemotype: Chemotype II
Receptors Studied: CB1, CB2, GPCR 55, TRPV1, TRPs, CB1 agonist, CB2 agonist
Citation: Ückert S, Hedlund P, Tsikas D, Kuczyk MA. The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract. World J Urol. 2025 Dec 6;44(1):26. doi: 10.1007/s00345-025-06045-x. PMID: 41351769; PMCID: PMC12681475.
