PRIMARY STUDY
The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat
Key Findings: This rat model of acute kidney injury (AKI) confirms that URB602 acts as a reactive oxygen species scavenger and anti-inflammatory mediator in renal ischemia-reperfusion injury (IRI), mainly depending on the activation of CB2.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China
Year of Pub: 2020
Cannabinoids Studied: AM-x Synthetic Cannabinoids, Synthetic Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, CB1 antagonist
Citation: Li XH, Liu YQ, Gong DY, Hai KR, Ke BW, Zuo YX. The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat. Shock. 2020 Oct;54(4):520-530. doi: 10.1097/SHK.0000000000001517. PMID: 32004183.
