RELATED STUDY
Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment
Key Findings: The results of this pilot study assessing tetrahydrocannabinol (THC) concentrations after oral ingestion were as expected: THC-rich extracts resulted in higher concentrations in mice. Unexpectedly, orally applied cannabidiol (CBD ) alleviated hypersensitivity in the nerve injury model, but THC did not.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Austria, Germany
Year of Pub: 2023
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabidiolic Acid (CBD-a), Tetrahydrocannabinolic Acid (THC-a), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV)
Phytocannabinoid Source: Cannabis Flower derived
Citation: Dumbraveanu C, Strommer K, Wonnemann M, Choconta JL, Neumann A, Kress M, Kalpachidou T, Kummer KK. Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment. Pharmaceutics. 2023 Mar 6;15(3):853. doi: 10.3390/pharmaceutics15030853. PMID: 36986714; PMCID: PMC10057980.
