PRIMARY STUDY

Select Minor Cannabinoids from Cannabis sativa Are Cannabimimetic and Antinociceptive in a Mouse Model of Chronic Neuropathic Pain

Key Findings:  This study found that four of the five minor cannabinoids [cannabinol (CBN), cannabidivarin (CBDV), cannabigerol (CBG), Δ8-tetrahydrocannabinol (Δ8-THC), and Δ9-tetrahydrocannabivarin (THCV)] showed cannabimimetic activity, while one was efficacious in relieving chronic neuropathic pain. Only CBN effectively relieved chemotherapy-induced peripheral neuropathy (CIPN) pain.