PRIMARY STUDY

Minor Cannabinoids as an Emerging Frontier for Pain Relief

Key Findings:  The minor cannabinoid cannabinol induces cannabimimetic effects such as hypothermia and reduced locomotion. Cannabigerol induced hypothermia and tail-flick antinociception in both sexes. Δ8-tetrahydrocannabinol stimulated antinociception, hypothermia, and catalepsy in both male and female mice. Low-dose Δ8-tetrahydrocannabinol affected only female mice, increasing cataleptic behavior and decreasing temperature. Δ9-tetrahydrocannabivarin induced three of the four tetrad endpoints, excluding locomotion, exclusively in female mice. Cannabidivarin displayed a minor but statistically significant antinociceptive effect in female but not male mice