PRIMARY STUDY

Use of phytocanabinoids in animal models of Parkinson's disease: Systematic review

Key Findings:  This analysis of the use of medicinal cannabis for the treatment of Prakinson's disease found that phytocannabinoids improved locomotor activity and involuntary movement and reduced catalepsy.

Type of Study:  Meta-analysis

Study Sample Size:  23

Study Result:  Positive

Study Location(s):  Brazil

Year of Pub:  2024


Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), WIN-x Synthetic Cannabinoids, Fatty Acid Amide Hydrolase (FAAH), Tetrahydrocannabivarin (THCV)

Phytocannabinoid Source:  Not Applicable

Chemotype:  Chemotype I, Chemotype III

Receptors Studied:  GPCR 55, TRPV1

Ligands Studied:  Dopamine, Serotonin

DOSING DETAILS   

Study Dosing Objective:  Effective Dose,

Established Protocol:  Effective dose

Route of Administration:  Injection, Oral (Ingestion)

Cannabinoid Ratio:  (CBD)   0    

Dosage Form:  Cannabidiol administered intraperitoneally

Dosing Regimen:  Cannabidiol 30 mg/kg

Treatment Duration:  14 days



Link to study