PRIMARY STUDY
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
Key Findings: Tetrahydrocannabivarin (THCV) is a potential inhibitor of the TRPV6 calcium-selective oncochannel, which appears to be involved in cell proliferation in human cancers. Results suggest THCV should be further studied as a novel therapeutic agent to target cancer cell proliferation via TPC channels.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Russia, United States
Year of Pub: 2023
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Isolate
Receptors Studied: TRPV2, TRPs
Route of Administration: In vitro
Citation: Neuberger A, et al. Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin. Nat Commun. 2023; 14:4630. doi: 10.1038/s41467-023-40362-2
Authors: Neuberger A, Trofimov YA, Yelshanskaya MV, Khau J, Nadezhdin KD, Khosrof LS, Krylov NA, Efremov RG, Sobolevsky AI
