RELATED STUDY

Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation

Key Findings:  Several cannabinoids modulate TRP receptors involved in pain, inflammation, and gut signaling:
CBD and THCV strongly activate TRPV3, while CBGV and CBGA are more effective at desensitizing this receptor than activating it.
CBDV and THCV also activate TRPV4 with moderate to high efficacy, whereas CBGA, CBGV, CBN, and CBG primarily act to desensitize TRPV4.
CBC reduces the expression of TRPV1β, TRPV3, and TRPV4 mRNA in the gut, suggesting anti-inflammatory potential via transcriptional regulation.
These findings highlight the nuanced role of cannabinoids in modulating TRP channel activity depending on their structure and target tissue.