Key Findings:  This review discusses the promising available research on the activity of cannabinoids on the skin's endocannabinoid system, which could result in effective treatments for atopic dermatitis, psoriasis, and allergic contact dermatitis conditions. Further human studies are needed, on topical preparations, as oral compounds appear to have more side effects than topical at this juncture.
Type of Study:  Meta-analysis
Study Result:  Positive
Study Location(s):  Portugal
Year of Pub:  2022
Cannabinoids Studied:  Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Tetrahydrocannabinolic Acid (THC-a), JWH-x Synthetic Cannabinoids, HU-x Synthetic Cannabinoids, SR-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Virodhamine (O-AEA), Cannabinoid (unspecified), Synthetic Cannabinoid (unspecified), Endocannabinoid (unspecified), Pharma THC, Pharma THC:CBD, Pharma CBD, Tetrahydrocannabivarin (THCV), Delta-8-THC, Palmitoylethanolamide (PEA)
Phytocannabinoid Source:  Unspecified
Terpenes Studied:  Limonene, Myrcene, Pinene
Receptors Studied:  CB1, CB2, TRPs, PPARs
Ligands Studied:  Serotonin