PRIMARY STUDY
Effects of non‐euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice
Key Findings: This study evaluated three cannabinoid compounds and their effects in a model of muscular degeneration. Results show, via the TRP channels in skeletal muscle, CBD, CBDV and THCV have anti-inflammatory activity, prevented loss of locomotor activity, and restored autophagy, suggesting potential therapeutic use in Duchenne muscular dystrophy (DMD).
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2018
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV)
Phytocannabinoid Source: Unspecified
Receptors Studied: TRPA1, TRPV1, TRPs
Route of Administration: In vitro, Injection
Citation: Iannotti FA, et al. Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice. Br J Pharmacol. 2019; 176:1568-1584. doi: 10.1111/bph.14460
Authors: Iannotti FA, Pagano E, Moriello AS, Alvino FG, Sorrentino NC, D'Orsi L, Gazzerro E, Capasso R, De Leonibus E, De Petrocellis L, Di Marzo V
