PRIMARY STUDY
Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents
Key Findings: The combination of CBD and THCV protected mice from Paclitaxel-induced peripheral neuropathy (PIPN). More specifically, the entourage effect associated with the co-administration of CBD and THCV against PIPN appears to protect neurons via 5HT1A and CB1 receptors sites.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1
Ligands Studied: Serotonin
Citation: Kumar Kalvala A, et al. Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents. Int Immunopharmacol. 2022; 107:108693. doi: 10.1016/j.intimp.2022.108693
Authors: Kumar Kalvala A, Bagde A, Arthur P, Kumar Surapaneni S, Ramesh N, Nathani A, Singh M
