PRIMARY STUDY
An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
Key Findings: THCV and CBDV both inhibited cannabinoid signaling in mice hippocampal neurons via the effects on CB1 and 2-AG-mediated signaling. Additional research is recommended on other ‘minor’ phytocannabinoids and highlights the need to test the interactions of phytocannabinoids with all components of the cannabinoid signaling system
Type of Study: Laboratory Study
Study Result: Inconclusive
Research Location(s): Czech Republic, United States
Year of Pub: 2021
Cannabinoids Studied: Cannabichromene (CBC), Tetrahydrocannabinol (THC), Cannabidiolic Acid (CBD-a), 2-Arachidonoyl Glycerol (2-AG), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Unspecified
Receptors Studied: CB1, CB2, TRPA1, TRPs
Route of Administration: In vitro
Citation: Straiker A, et al. An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models. Molecules. 2021; 26:(unknown pages). doi: 10.3390/molecules26175352
Authors: Straiker A, Wilson S, Corey W, Dvorakova M, Bosquez T, Tracey J, Wilkowski C, Ho K, Wager-Miller J, Mackie K
