RELATED STUDY
Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Actions of Phytocannabinoids or Endocannabinoids on TRPA1 and TRPV1 Channels
Key Findings: This study found that common terpenoids found in cannabis did not activate TRPA1 and TRPV1 receptor nor did they modulate their activation by cannabinoids, other agonists, or endocannabinoids.
Type of Study: Laboratory Study
Study Result: Negative
Research Location(s): Australia
Year of Pub: 2021
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Tetrahydrocannabinol (THC), Cannabichromenic Acid (CBC-a), Cannabidiolic Acid (CBD-a), Cannabigerolic Acid (CBG-a), Tetrahydrocannabinolic Acid (THC-a), Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Isolate
Terpenes Studied: ß-Caryophyllene, Humulene, Limonene, Linalool, Myrcene, Pinene
Receptors Studied: CB1, CB2, TRPA1, TRPV1
Route of Administration: In vitro
Citation: Heblinski M, et al. Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Actions of Phytocannabinoids or Endocannabinoids on TRPA1 and TRPV1 Channels. Cannabis Cannabinoid Res. 2020; 5:305-317. doi: 10.1089/can.2019.0099
Authors: Heblinski M, Santiago M, Fletcher C, Stuart J, Connor M, McGregor IS, Arnold JC
