PRIMARY STUDY
The phytocannabinoid, Δ⁹-tetrahydrocannabivarin, can act through 5-HT₁A receptors to produce antipsychotic effects
Key Findings: Resulting data suggests that THCV can enhance 5-HT₁A receptor activation. The authors posit that THCV may have therapeutic potential in ameliorating some of the negative, cognitive and positive symptoms associated with schizophrenia.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United Kingdom
Year of Pub: 2015
Cannabinoids Studied: Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Unspecified
Ligands Studied: Serotonin
Citation: Cascio MG, et al. The phytocannabinoid, Δ⁹-tetrahydrocannabivarin, can act through 5-HT₁A receptors to produce antipsychotic effects. Br J Pharmacol. 2015; 172:1305-18. doi: 10.1111/bph.13000
Authors: Cascio MG, Zamberletti E, Marini P, Parolaro D, Pertwee RG
