PRIMARY STUDY
High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain
Key Findings: Data revealed that weight changes induced by THCV and rimonabant were in part mediated by modulation of GPR55 (notably THCV acted an agonist or an antagonist depending on the assay).
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United Kingdom
Year of Pub: 2020
Cannabinoids Studied: SR-x Synthetic Cannabinoids, Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Unspecified
Receptors Studied: CB1
Route of Administration: Oral (Ingestion)
Citation: Wargent ET, et al. High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain. PeerJ. 2020; 8:e9811. doi: 10.7717/peerj.9811
Authors: Wargent ET, Kepczynska M, Zaibi MS, Hislop DC, Arch JRS, Stocker CJ
