PRIMARY STUDY
The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo
Key Findings: This animal trials found that Delta-8-THCV and Delta-9-THCV (Ki at CB1 75.4nM) antagonize Delta-9-THC in vivo.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United Kingdom
Year of Pub: 2007
Cannabinoids Studied: Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Unspecified
Receptors Studied: CB1
Route of Administration: Injection
Citation: Pertwee RG, et al. The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo. Br J Pharmacol. 2007; 150:586-94. doi: 10.1038/sj.bjp.0707124
Authors: Pertwee RG, Thomas A, Stevenson LA, Ross RA, Varvel SA, Lichtman AH, Martin BR, Razdan RK
