PRIMARY STUDY
The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial
Key Findings: Data showed that THCV inhibited some effects of THC (e.g. reduced THC-induced increased heart rate), while potentiating others (i.e. significantly increased memory intrusions).
Type of Study: Double Blind Clinical Trial
Study Sample Size: 10
Study Result: Inconclusive
Research Location(s): United Kingdom
Year of Pub: 2016
Cannabinoids Studied: Tetrahydrocannabinol (THC), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype I
Dosage: 10mg pure THCV or placebo daily x 5 days, followed by 1mg intravenous THC on the fifth day.
Route of Administration: Injection, Oral (Ingestion)
Citation: Englund A, et al. The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. J Psychopharmacol. 2016; 30:140-51. doi: 10.1177/0269881115615104
Authors: Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P
