Key Findings:  The authors conclude that cannabis-based therapeutics can be a low-cost and well-tolerated therapeutic option to mitigate signs and symptoms of fibromyalgia as well as improve their quality of life.
Type of Study:  Double Blind Clinical Trial
Study Sample Size:  17
Study Result:  Positive
Study Location(s):  Brazil
Year of Pub:  2020
Cannabinoids Studied:  Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source:  Cannabis Flower derived
Chemotype:  Chemotype I
Terpenes Studied:  ß-Caryophyllene, Myrcene, Pinene
DOSING DETAILS   
Study Dosing Objective:  Effective Dose
Established Protocol:  Effective dose
Route of Administration:  Oral (Ingestion)
Cannabinoid Ratio:  (THC : CBD)   61 : 1    
Dosage Form:  White Widow variety, at a 24.44-mg/mL concentration of THC and 0.51 mg/mL of CBD—at a proportion of ∼48/1 THC/CBD
Dosing Regimen:  Mean 3.6 drops a day (4.4 mg of THC and 0.08 mg of CBD)
Starting Dose:  One drop (∼1.22 mg of THC and 0.02 mg of CBD) a day
Titration:  Increases were titrated to effect
Treatment Duration:  8 weeks
Adverse Events:  There was no follow-up loss by unpleasant adverse effects.
Additional Notes:  Dose Titration