PRIMARY STUDY
Δ8-Tetrahydrocannabivarin Prevents Hepatic Ischaemia/Reperfusion Injury by Decreasing Oxidative Stress and Inflammatory Responses Through Cannabinoid CB2 Receptors
Key Findings: CB2 activation via Δ(8) -THCV (a synthetic analogue of the plant cannabinoid Δ(9) -THCV) activated decreased tissue injury and inflammation associated with ischaemia-reperfusion injury.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2012
Cannabinoids Studied: Cannabinoid (unspecified), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Citation: Bátkai S, et al. Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors. Br J Pharmacol. 2012; 165:2450-61. doi: 10.1111/j.1476-5381.2011.01410.x
Authors: Bátkai S, Mukhopadhyay P, Horváth B, Rajesh M, Gao RY, Mahadevan A, Amere M, Battista N, Lichtman AH, Gauson LA, Maccarrone M, Pertwee RG, Pacher P
