Key Findings:  The data suggested that cannabis, composed of THC among other exocannabinoids, was independently associated with a lower risk of NAFLD. Therefore, tolerance of CB1 from repetitive THC use may be the mechanism behind the inverse relationship that was noted in this study population.
Type of Study:  Meta-analysis
Study Result:  Positive
Research Location(s):  United States
Year of Pub:  2019
Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source:  Not Applicable
Ligands Studied:  Anti-inflammatory cytokines
Citation:  Dibba P, et al. Potential Mechanisms Influencing the Inverse Relationship Between Cannabis and Nonalcoholic Fatty Liver Disease: A Commentary. Nutr Metab Insights. 2019; 12:1178638819847480. doi: 10.1177/1178638819847480
Authors:  Dibba P, Li AA, Cholankeril G, Ali Khan M, Kim D, Ahmed A