PRIMARY STUDY
Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis
Key Findings: This study demonstrates that Δ9-tetrahydrocannabivarin protects adipose-derived mesenchymal stem cells from endoplasmic reticulum stress by restoring cellular architecture, migration, and proliferation, modulating inflammatory and apoptotic responses, and downregulating unfolded protein response gene expression, suggesting therapeutic potential in obesity-related metabolic disorders.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Poland
Year of Pub: 2026
Cannabinoids Studied: Tetrahydrocannabivarin (THCV)
Phytocannabinoid Source: Not Applicable
Route of Administration: , In vitro
Citation: Kowalczuk A, Marycz K, Kornicka J, Groborz S, Meissner J, Mularczyk M. Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis. Int J Mol Sci. 2023 Apr 12;24(8):7120. doi: 10.3390/ijms24087120. PMID: 37108282; PMCID: PMC10138341.
