PRIMARY STUDY

Aromatisation-based extract engineering of Cannabis sativa L. Unveils rare cannabinoids with anticancer potential

Key Findings:  This study proposes an innovative strategy for the extract engineering of rare varin-type cannabinoids from abundant precursors. Nine cannabinoid analogues, including 4 rare varin-type, were synthesised and applied to five human cancer cell lines. CBNV and Δ6a,10a-THCV showed the most promising anticancer activity against breast and colon cancer cells.