PRIMARY STUDY
Cannabinoids in cancer treatment: Therapeutic potential and legislation
Key Findings: This review of the literature on the anticancer effects of plant-derived and synthetic cannabinoids finds that they can effectively modulate tumor growth in both in vivo and in vitro studies. Effects, however, depend on the cancer type and drug dose/concentration.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Slovenia
Year of Pub: 2019
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabigerolic Acid (CBG-a), WIN-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Synthetic Cannabinoid (unspecified), Pharma THC, Pharma CBD, Tetrahydrocannabivarin (THCV), Delta-8-THC
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, GPCR 55, TRPA1, TRPV1, TRPV2, TRPM8, PPARs
Ligands Studied: Serotonin, Pro-inflammatory cytokines
Citation: Dariš B, Tancer Verboten M, Knez Ž, Ferk P. Cannabinoids in cancer treatment: Therapeutic potential and legislation. Bosn J Basic Med Sci. 2019 Feb 12;19(1):14-23. doi: 10.17305/bjbms.2018.3532. PMID: 30172249; PMCID: PMC6387667.
