PRIMARY STUDY
Recent Advances in the Therapeutic Potential of Cannabinoids Against Gliomas: A Systematic Review (2022-2025)
Key Findings: This review discusses the most recent research on the anti-cancer mechanisms of cannabinoids, including ferroptosis induction, mitochondrial dysfunction, integrated stress response activation, and epigenetic modulation. The mechanisms and discrepancies from the current data warrant further research before cannabinoids can be used in standard care.
Type of Study: Meta-analysis
Study Sample Size: 45
Study Result: Positive
Research Location(s): China, Croatia, United Kingdom
Year of Pub: 2025
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabidiolic Acid (CBD-a), Cannabigerolic Acid (CBG-a), AM-x Synthetic Cannabinoids, Cannabinoid (unspecified), Synthetic Cannabinoid (unspecified), Pharma THC, Pharma CBD, Tetrahydrocannabivarin (THCV), Delta-8-THC
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, GPCR 55, TRPV1
Citation: Javid FA, Belancic A, Kwok MK, Lam YW. Recent Advances in the Therapeutic Potential of Cannabinoids Against Gliomas: A Systematic Review (2022-2025). Pharmacol Res Perspect. 2025 Aug;13(4):e70160. doi: 10.1002/prp2.70160. PMID: 40781861; PMCID: PMC12334796.
