PRIMARY STUDY
Molecular brain differences and cannabis involvement: A systematic review of positron emission tomography studies
Key Findings: This comprehensive systematic review evaluated PET images comparing cannabis users and those with cannabis use disorder and found substantive molecular differences in the dopamine and endocannabinoid systems, and in global brain metabolism.
Type of Study: Clinical Meta-analysis
Study Sample Size: 20
Study Result: Negative
Research Location(s): Canada
Year of Pub: 2023
Cannabinoids Studied: Fatty Acid Amide Hydrolase (FAAH), Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Unspecified
Receptors Studied: CB1
Ligands Studied: Dopamine
Citation: Xu H, et al. Molecular brain differences and cannabis involvement: A systematic review of positron emission tomography studies. J Psychiatr Res. 2023; 162:44-56. doi: 10.1016/j.jpsychires.2023.03.045
Authors: Xu H, Owens MM, Farncombe T, Noseworthy M, MacKillop J
