PRIMARY STUDY
Preclinical Assessment of the Abuse Potential of Purified Botanical Cannabidiol: Self-Administration, Drug Discrimination, and Physical Dependence
Key Findings: This study investigated studies on the abuse potential of cannabidiol (CBD) in rats and nonhuman primates (NHP) and found that CBD is unlikely to cause physical dependence and has a very low potential for abuse.
Type of Study: Meta-analysis
Study Sample Size: 19
Study Result: Positive
Research Location(s): United States
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD), Pharma CBD
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Route of Administration: Injection, Oral (Ingestion)
Citation: Gray RA, et al. Preclinical Assessment of the Abuse Potential of Purified Botanical Cannabidiol: Self-Administration, Drug Discrimination, and Physical Dependence. J Pharmacol Exp Ther. 2022; 382:54-65. doi: 10.1124/jpet.121.000988
Authors: Gray RA, Heal DJ, Maguire DR, Gerak LR, Javors MA, Smith S, France CP
