PRIMARY STUDY
Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2)
Key Findings: This study of rats concludes that the hippocampal endogenous endocannabinoid system is crucial in the suppression of METH intake, and could be a promising target for future studies in the treatment of addiction.
Type of Study: Animal Study
Study Result: Inconclusive
Research Location(s): United States
Year of Pub: 2022
Cannabinoids Studied: Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2
Ligands Studied: Dopamine, Glutamate, Neurotransmitter (unspecified/other)
Citation: Jayanthi S, et al. Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2). Mol Neurobiol. 2022; 59:1238-1248. doi: 10.1007/s12035-021-02656-8
Authors: Jayanthi S, Peesapati R, McCoy MT, Ladenheim B, Cadet JL
