PRIMARY STUDY
Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein
Key Findings: This study modeling ORF8, ORF10, and M protein from the SARS- CoV-2 infection using infected cells found that cells exposed to cannabidiol (CBD) had overall reduced cell numbers, and increased early and late cell death. Thses results suggest a potential role of CBD in the innate immune system and RNA-type viral infections.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Canada
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Ligands Studied: Pro-inflammatory cytokines
Route of Administration: In vitro
Citation: Fernandes MF, et al. Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein. Life Sci. 2022; 301:120624. doi: 10.1016/j.lfs.2022.120624
Authors: Fernandes MF, Chan JZ, Hung CCJ, Tomczewski MV, Duncan RE
